ABC lipid transporters
Wagner, E. M. National Heart, Lung and Blood Institutes, National Institutes of Health, Bethesda, Maryland.
Basso, F. National Heart, Lung and Blood Institutes, National Institutes of Health, Bethesda, Maryland.
Kim, C. S. National Heart, Lung and Blood Institutes, National Institutes of Health, Bethesda, Maryland.
Amar, M. J. A. National Heart, Lung and Blood Institutes, National Institutes of Health, Bethesda, Maryland.
Last reviewed:August 2019
- ABCG5 and ABCG8
- Related Primary Literature
- Additional Reading
A family of adenosine triphosphate–binding cassette (ABC) transmembrane proteins that use energy to transport various molecules across extracellular and intracellular membranes (cytoplasmic membranes, endoplasmic reticulum, mitochondria, or peroxisomes). ABC lipid transporters consist of two hydrophobic transmembrane domains and two hydrophilic nucleotide-binding folds. These binding folds contain highly conserved sequence motifs (Walker A and B) and are separated by a linker sequence, also known as the signature (C) motif. ABC transporters are organized as full transporters or half transporters depending on the number of transmembrane domains and nucleotide-binding folds. Half transporters must form homodimers or heterodimers to be functional.
The content above is only an excerpt.
for your institution. Subscribe
To learn more about subscribing to AccessScience, or to request a no-risk trial of this award-winning scientific reference for your institution, fill in your information and a member of our Sales Team will contact you as soon as possible.
to your librarian. Recommend
Let your librarian know about the award-winning gateway to the most trustworthy and accurate scientific information.
AccessScience provides the most accurate and trustworthy scientific information available.
Recognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Contributors include more than 10,000 highly qualified scientists and 45 Nobel Prize winners.
MORE THAN 8700 articles covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology
115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms
3000 biographies of notable scientific figures
MORE THAN 19,000 downloadable images and animations illustrating key topics
ENGAGING VIDEOS highlighting the life and work of award-winning scientists
SUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research
LINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information