Article
Article
Cholesteryl ester transfer protein (CETP)
Article By:
McPherson, Ruth Division of Cardiology, University of Ottawa Heart Institute, Ottowa, Canada.
Last reviewed:December 2019
DOI:https://doi.org/10.1036/1097-8542.900195
A 74-kilodalton (kDa) hydrophobic glycoprotein that plays a central role in human high-density lipoprotein (HDL) metabolism and reverse cholesterol transport. Cholesteryl ester transfer protein (CETP) mediates the exchange of neutral lipid (both heteroexchange, which is the net transfer of cholesteryl ester between lipoproteins in exchange for triglyceride and homoexchange, which is the bidirectional transfer of the same lipid) between apolipoprotein (apo) A-I- and apoB-containing lipoproteins (Fig. 1). See also: Cholesterol; Lipid; Lipid metabolism; Lipoprotein
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