Article
Article
Cyclic nucleotides
Article By:
Uhler, Michael D. Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan.
Last reviewed:December 2019
DOI:https://doi.org/10.1036/1097-8542.176000
Derivatives of nucleic acids that control the activity of several proteins within cells to regulate and coordinate metabolism. Cyclic nucleotides are members of a group of molecules known as intracellular second messengers; their levels are regulated by hormones and neurotransmitters, which are the extracellular first messengers in a regulatory pathway. Cyclic nucleotides are found naturally in living cells, from bacteria, to yeast, to human cells. See also: Metabolism
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