Article
Article
Gel permeation chromatography
Article By:
Cooper, Anthony R. Lockheed Missiles and Space Company, Inc., Palo Alto, California.
Last reviewed:January 2020
DOI:https://doi.org/10.1036/1097-8542.283900
A separation technique involving the transport of a liquid mobile phase through a column containing the separation medium, a porous material. Gel permeation chromatography (GPC), also called size exclusion chromatography and gel filtration, affords a rapid method for the separation of oligomeric and polymeric species. The separation is based on differences in molecular size in solution. It is of particular importance for research in biological systems and is the method of choice for determining molecular weight distribution of synthetic polymers.
The content above is only an excerpt.
About AccessScience
AccessScience provides the most accurate and trustworthy scientific information available.
Recognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Contributors include more than 10,000 highly qualified scientists and 46 Nobel Prize winners.
MORE THAN 8700 articles covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology
115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms
3000 biographies of notable scientific figures
MORE THAN 19,000 downloadable images and animations illustrating key topics
ENGAGING VIDEOS highlighting the life and work of award-winning scientists
SUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research
LINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information
