Article
Article
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Genomics of depression
Article By:
Sibille, Etienne Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania.
Last reviewed:2013
DOI:https://doi.org/10.1036/1097-8542.YB133335
Depression has been characterized recently as “a heterogeneous disorder with a highly variable course, an inconsistent response to treatment, and no established mechanism.” This alarming characterization for the disease that is the leading worldwide cause of years lost as a result of disability potentially reflects a fundamental flaw in previous experimental approaches that have focused on few candidate biological systems to understand the pathology of the illness. Recent genome-wide or “genomic” approaches depart from these traditional investigations because they rely on the unbiased knowledge of the whole genome to identify changes in the structure or function of genes in association with the disease.
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