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Article
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HIV and bone marrow transplantation
Article By:
Shors, Teri Department of Biology and Microbiology, University of Wisconsin, Oshkosh, Wisconsin.
Last reviewed:2012
DOI:https://doi.org/10.1036/1097-8542.YB120216
This article chronicles a novel treatment that saved a patient from two different diseases, one of which was thought to be incurable. The patient was infected with human immunodeficiency virus (HIV) and also suffered from acute myeloid leukemia (AML). Based on research known about HIV's interactions with T-cells, doctors tailored the patient's treatment to not only be an effective cancer treatment for AML but also a treatment to cure the patient's HIV infection. HIV infects T-cells, which are specialized immune cells that are depleted as the course of HIV infection progresses in the patient. The patient received a bone marrow transplantation from a donor who had a natural resistance to HIV infection. Bone marrow transplantation is also part of the protocol to treat leukemia patients in addition to chemotherapy and radiation treatment.
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