Article
Article
- Biology & Biomedicine
- Biochemistry and molecular biology
- KAP1 protein
- Biology & Biomedicine
- Genetics
- KAP1 protein
DISCLAIMER: This article is being kept online for historical purposes. Though accurate at last review, it is no longer being updated. The page may contain broken links or outdated information.
KAP1 protein
Article By:
Farnham, Peggy J. Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California.
Last reviewed:2013
DOI:https://doi.org/10.1036/1097-8542.YB130066
- KAP1 and transcriptional silencing
- KAP1 and repair of damaged DNA
- KAP1 and apoptosis
- Should KAP1 be targeted for inhibition in tumors?
- Conclusions
- Related Primary Literature
The protein KAP1 (also called TRIM28) is expressed at low to moderate levels in most normal tissues. However, it is upregulated (that is, it has increased expression) in many human cancers, and it has been suggested that inhibition of KAP1 function may be a rational approach for cancer treatment. KAP1 is involved in regulating several cellular pathways, and it is critical to define the normal role of KAP1 to understand how targeting KAP1 might affect tumor growth and/or response to chemotherapeutic agents. Studies in which the levels of KAP1 have been artificially manipulated have suggested that KAP1 plays different roles in different cells. For example, KAP1 has been shown to be essential both for maintaining the pluripotency (that is, the capacity to generate any cell type in the body) of embryonic stem cells and for allowing these stem cells to properly differentiate. Similarly, studies of adult cells have indicated that KAP1 can either promote or inhibit cell differentiation, depending on the cell type. Insight into how KAP1 can have such diverse functions has come from identifying its protein interaction partners. This article focuses on three KAP1-containing complexes that are proposed to inhibit transcription [the process by which deoxyribonucleic acid (DNA) is transcribed into ribonucleic acid (RNA), which is then translated into the proteins that function to create the different types of body cells], facilitate DNA repair (the process by which the cell identifies and corrects damaged regions of the genome), and inhibit apoptosis (a programmed cell death pathway that controls various aspects of normal development and helps rid the body of unwanted or damaged cells).
The content above is only an excerpt.
for your institution. Subscribe
To learn more about subscribing to AccessScience, or to request a no-risk trial of this award-winning scientific reference for your institution, fill in your information and a member of our Sales Team will contact you as soon as possible.
to your librarian. Recommend
Let your librarian know about the award-winning gateway to the most trustworthy and accurate scientific information.
About AccessScience
AccessScience provides the most accurate and trustworthy scientific information available.
Recognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Contributors include more than 10,000 highly qualified scientists and 46 Nobel Prize winners.
MORE THAN 8700 articles covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology
115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms
3000 biographies of notable scientific figures
MORE THAN 19,000 downloadable images and animations illustrating key topics
ENGAGING VIDEOS highlighting the life and work of award-winning scientists
SUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research
LINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information