Article
Article
- Biology & Biomedicine
- Physiology
- Melatonin
Melatonin
Article By:
Blask, David E. Laboratory of Experimental Neuroendocrinology/Oncology, Bassett Research Institute, Cooperstown, New York.
Last reviewed:January 2020
DOI:https://doi.org/10.1036/1097-8542.900164
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- Melatonin, published June 2014:Download PDF Get Adobe Acrobat Reader
- Generation and regulation of the melatonin rhythm
- Melatonin in plants
- Physiological and pharmacological actions
- Disease states and clinical applications
- Related Primary Literature
- Additional Reading
A hormone secreted primarily by the pineal gland in the vertebrate brain that conveys information about time that influences reproduction and circadian physiology. Derived from the essential amino acid tryptophan, melatonin (C13H16N2O2; see illustration) was discovered in 1958 and was originally named for its ability to disperse pigments in skin cells of the frog (it has since been shown to act on melanophores in the skins of amphibians and reptiles and to concentrate the melanin in the center of the cells, lightening the body surface). It is an indoleamine molecule that is found widely throughout nature. See also: Brain; Hormone; Pigmentation; Pineal gland
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