Article
Article
Oxime
Article By:
Johnson, James E. Department of Chemistry, Texas Woman's University, Denton, Texas.
Last reviewed:January 2020
DOI:https://doi.org/10.1036/1097-8542.480600
One of a group of chemical substances with the general formula RR′C
N
OH, where R and R′ represent any carbon group or hydrogen. Oximes are derived from aldehydes (aldoximes, RHCNOH) and ketones (ketoximes, RR′CNOH, where R and R′ are not hydrogen). Oximes and oxime ethers (RR′CNOR″) have important pharmaceutical and synthetic applications. The oxime (and oxime ether) functional group is incorporated into many organic medicinal agents, including some antibiotics, for example, gemifloxacin mesylate (see structure); and pralidoxime chloride (see structure) and obidoxime chloride are used in the treatment of poisoning by organophosphate insecticides malathion and diazinon. See also: Aldehyde; Ketone
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