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Sestrins
Article By:
Lee, Jun Hee Department of Pharmacology, University of California at San Diego, La Jolla, California.
Last reviewed:2012
DOI:https://doi.org/10.1036/1097-8542.YB120292
Sestrins are a family of proteins. Originally discovered in 1999, they are observed in most animals. There are three Sestrins—Sestrin1, Sestrin2, and Sestrin3—in mammals, whereas only a single Sestrin can be found in most invertebrates. Studies have shown that Sestrins accumulate in cells and tissues that have been exposed to environmental stresses, such as irradiation, oxidative damage, hypoxia (oxygen deficiency), and chemical stresses (Fig. 1). Sestrins can exert antioxidant and antigrowth effects that can protect cells from stress-induced damages and their detrimental consequences. Recent studies have also demonstrated that Sestrins have important physiological functions that protect animals from diverse age-associated diseases that are promoted by stresses.
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