Article
Article
Combinatorial synthesis
Article By:
Uozumi, Yasuhiro Laboratory of Complex Catalysis, Institute for Molecular Science, Okazaki, Japan.
Last reviewed:January 2020
DOI:https://doi.org/10.1036/1097-8542.800190
A method for preparing a large number of chemical compounds, commonly known as a combinatorial library, which are then screened to identify compounds having a desired function, such as a particular biological or catalytic activity. Combinatorial synthesis is an aspect of combinatorial chemistry, which allows for the simultaneous generation and rapid testing for a desired property of large numbers of chemically related compounds. One could regard combinatorial chemistry as the scientist's attempt to mimic the natural principles of random mutation and selection of the fittest. Combinatorial chemistry has already become an invaluable tool in the areas of molecular recognition, materials science, drug discovery and optimization, and catalyst development. See also: Combinatorial chemistry; Organic synthesis
The content above is only an excerpt.
About AccessScience
AccessScience provides the most accurate and trustworthy scientific information available.
Recognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Contributors include more than 10,000 highly qualified scientists and 46 Nobel Prize winners.
MORE THAN 8700 articles covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology
115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms
3000 biographies of notable scientific figures
MORE THAN 19,000 downloadable images and animations illustrating key topics
ENGAGING VIDEOS highlighting the life and work of award-winning scientists
SUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research
LINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information
