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Decarboxylative couplings
Article By:
Gooßen, Lukas J. Fachbereich Chemie, Universität Kaiserslautern, Straße, Germany.
Rodríguez, Nuria Fachbereich Chemie, Universität Kaiserslautern, Straße, Germany.
Gooßen, Käthe Fachbereich Chemie, Universität Kaiserslautern, Straße, Germany.
Last reviewed:2011
DOI:https://doi.org/10.1036/1097-8542.YB110008
A decarboxylative coupling is a chemical reaction in which a carboxylic acid extrudes a molecule of carbon dioxide (CO2) and in its place forms a bond with an electrophilic carbon atom or heteroatom. The reaction can be employed, for example, in the regioselective synthesis of biaryls from aromatic or heteroaromatic carboxylates and aryl halides or pseudohalides, or for the analogous synthesis of aryl ketones from α-oxocarboxylates [reaction (1)].
(1)
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