Proteomics

Article By:

Lim, Megan S. Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

Elenitoba-Johnson, Kojo S. J. Department of Pathology, University of Michigan, Ann Arbor, Michigan.

Last reviewed:January 2021

DOI:https://doi.org/10.1036/1097-8542.900125

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• Proteomics, published 2014:Download PDF Get Adobe Acrobat Reader

The study of the proteome (the total protein complement of a cell, a tissue, or an entire organism). Proteomics is the scientific investigation of the proteome, that is, the entire collection of proteins produced by the cells in an organism. Overall, proteomics involves comprehensive approaches to study protein expression, posttranslational modification, interactions, organization, and function (Fig. 1). Importantly, analysis of protein derangements on a proteome-wide scale can reveal insights into deregulated pathways and networks involved in the pathogenesis of disease. Additionally, proteomic studies could lead to identification of biomarkers that are important for the early detection, diagnosis, prognosis, and treatment of human diseases. See also: Disease; Pathology; Protein

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